INCI Name Copper Tripeptide-1
CAS Number 89030-95-5
Copper Tripeptide-1 is a synthetic anti-aging ingredient widely used in cosmetics. It firms skin, reduces wrinkles, and acts as a powerful antioxidant to protect and rejuvenate. Naturally present in body fluids, it also promotes hair growth. Known as Copper Peptide or GHK-Cu, it appears as a blue powder with the formula C14H22N6O4Cu.
Origin
For cosmetics, Copper Tripeptide-1 is synthetically produced by first creating a tripeptide made of glycine, histidine, and lysine. Copper ions are then chelated into this peptide, forming the stable this complex, which is purified for use in skincare products.
Purpose
Copper Tripeptide-1 is a powerful antioxidant that protects skin from environmental damage while conditioning it to improve firmness and texture. Additionally, it soothes irritation and redness, making it ideal for calming sensitive or damaged skin.
| Feature | Description |
| Name | Copper Tripeptide-1 (GHK-Cu) |
| Type | Peptide complex, skin-conditioning and anti-aging agent |
| Source | Synthetic |
| Ph | 4.0–6.0 |
| Color | Blue powder |
| Odor | Odorless to mild |
| Solubility | Soluble in water and water-based solvents |
| Concentration | 0.01%–0.1% |
| Physical state | Fine crystalline powder |
Chemical Structure and Composition
Copper Tripeptide-1, also known as GHK-Cu, is a small, naturally occurring tripeptide consisting of glycine, histidine, and lysine, chelated with a copper ion. This unique structure allows it to interact effectively with skin cells, promoting various biological activities essential for skin health and regeneration.
Skin Regeneration and Healing
Copper Tripeptide-1 accelerates wound healing by stimulating the synthesis of collagen, elastin, and glycosaminoglycans. These molecules form the extracellular matrix, providing structural support and elasticity to the skin, which helps repair damaged tissues and improves skin texture.
Anti-Aging and Firming Effects
By promoting collagen and elastin production, this reduces fine lines, wrinkles, and skin laxity. It enhances skin firmness and elasticity, contributing to a more youthful, lifted, and revitalized appearance.
Powerful Antioxidant Protection
This peptide complex effectively neutralizes free radicals generated by UV radiation, pollution, and other environmental stressors. Its antioxidant properties prevent oxidative damage to skin cells, slowing down the aging process and protecting skin vitality.
Anti-Inflammatory and Soothing Properties
Copper Tripeptide-1 has been shown to reduce inflammation and soothe irritated skin. It supports the repair of the skin barrier and is beneficial for sensitive, acne-prone, or inflamed skin, helping to reduce redness and promote calmness.
Hair Growth Stimulation
An additional benefit of Copper Tripeptide-1 is its ability to stimulate hair follicle activity, promoting hair growth, increasing density, and improving hair thickness. This makes it valuable in hair care formulations targeting hair loss and thinning.
Skin Conditioning and Hydration
Copper Tripeptide-1 improves skin conditioning by enhancing hydration levels and smoothing skin texture. It supports moisture retention and strengthens the skin barrier, resulting in soft, supple, and well-moisturized skin.
Bioavailability and Skin Penetration
Due to its small size and copper chelation, this exhibits high bioavailability and penetrates the skin efficiently. This allows it to reach deeper skin layers and exert its beneficial effects more effectively than larger molecules.
Formulation Stability and Compatibility
Copper Tripeptide-1 is chemically stable under appropriate formulation conditions. It is compatible with a wide range of cosmetic ingredients and can be incorporated into serums, creams, lotions, and hair care products without losing efficacy.
Safety Profile and Usage Considerations
Copper Tripeptide-1 is generally safe and well-tolerated by most skin types. However, formulators should avoid excessive copper exposure, and users should follow product directions carefully to minimize potential irritation or unwanted facial hair growth.
Shelf Life and Storage Recommendations
The typical shelf life of this is between 12 to 24 months when stored properly.To preserve its stability and activity, store it in airtight, opaque containers at cool temperatures between 2°C and 8°C (36°F to 46°F), and keep it away from direct sunlight and humidity.
Applications of Copper Tripeptide-1 in Skincare
Anti-Aging Serums and Creams
Copper Tripeptide-1 is widely used in anti-aging skincare products due to its ability to stimulate collagen and elastin production. It helps reduce fine lines, wrinkles, and sagging skin, making it a popular active ingredient in serums and creams designed to restore youthful skin texture and firmness.
Wound Healing and Skin Repair Products
Thanks to its skin regeneration properties, this is incorporated into formulations aimed at accelerating the healing of minor wounds, burns, and skin damage. It supports tissue repair and reduces the appearance of scars, making it ideal for post-procedure skincare products.
Moisturizers and Skin Conditioners
Copper Tripeptide-1 enhances skin hydration and improves overall skin texture. It is commonly added to moisturizers and skin conditioners to promote smooth, supple skin and strengthen the skin barrier against environmental stress.
Soothing and Sensitive Skin Formulations
Its anti-inflammatory and calming effects make this suitable for products targeting sensitive, irritated, or acne-prone skin. It helps reduce redness and inflammation while supporting skin barrier repair.
Haircare Products
While primarily used in skincare, this is also valued in haircare formulations. It promotes hair follicle health and stimulates hair growth, making it a beneficial ingredient in shampoos, scalp treatments, and conditioners for thinning hair.
Eye Care Products
Because it firms and fights aging, formulators use this ingredient in eye creams and serums to reduce crow’s feet, puffiness, and dark circles, improving the delicate skin around the eyes.
Sun Protection and Repair
Some advanced formulations include this to help repair UV damage and support skin recovery after sun exposure. Its antioxidant properties also enhance the skin’s defense against environmental aggressors.
